| 2012 NL Leaders | |||||||||||||
| Name | Age | Team | G | IP | TBF | BB% | K% | BABIP | LOB% | GB% | HR/Air | ERA | FIP |
| Michael Ekstrom | 29 | Colorado | 15 | 15.67 | 72 | 2.8% | 12.5% | .370 | 56% | 44% | 3% | 6.32 | 3.19 |
| Kenneth Herndon | 27 | Philadelphia | 5 | 7.67 | 33 | 3.0% | 24.2% | .429 | 73% | 46% | 8% | 4.69 | 3.13 |
| Wilton Lopez | Houston | 64 | 66.33 | 260 | 3.1% | 20.8% | .310 | 81% | 55% | 5% | 2.17 | 2.74 | |
| Edward Mujica | 28 | St. Louis | 29 | 26.33 | 97 | 3.1% | 21.6% | .271 | 93% | 51% | 3% | 1.03 | 2.37 |
| Joe Blanton | 32 | Philadelphia | 21 | 133.33 | 560 | 3.2% | 20.5% | .304 | 67% | 43% | 9% | 4.59 | 4.02 |
| Cliff Lee | 34 | Philadelphia | 30 | 211.00 | 847 | 3.3% | 24.4% | .313 | 79% | 46% | 8% | 3.16 | 3.17 |
| Jonathan Broxton | 28 | Cincinnati | 25 | 22.33 | 87 | 3.4% | 23.0% | .306 | 75% | 49% | 3% | 2.82 | 2.46 |
| Chad Qualls | 34 | Pittsburgh | 17 | 13.67 | 58 | 3.4% | 10.3% | .292 | 31% | 55% | 0% | 6.58 | 2.69 |
| Daniel Otero | San Francisco | 12 | 12.33 | 57 | 3.5% | 14.0% | .409 | 50% | 71% | 0% | 5.84 | 2.80 | |
| Jean Machi | 29 | San Francisco | 8 | 6.67 | 28 | 3.6% | 14.3% | .238 | 58% | 39% | 14% | 6.75 | 6.28 |
| Jorge De La Rosa | 31 | Colorado | 3 | 10.67 | 53 | 3.8% | 11.3% | .308 | 42% | 34% | 17% | 9.28 | 8.66 |
| Jeff Karstens | 30 | Pittsburgh | 19 | 90.67 | 372 | 4.0% | 17.7% | .295 | 68% | 38% | 4% | 3.97 | 3.35 |
| Christopher Leroux | Pittsburgh | 10 | 11.33 | 48 | 4.2% | 25.0% | .323 | 40% | 50% | 6% | 5.56 | 2.95 | |
| Julio Teheran | 22 | Atlanta | 2 | 6.33 | 24 | 4.2% | 20.8% | .278 | 33% | 24% | 0% | 5.69 | 2.02 |
| Chris Carpenter | 37 | St. Louis | 3 | 17.00 | 72 | 4.2% | 16.7% | .269 | 77% | 42% | 6% | 3.71 | 4.13 |
| Christian Garcia | 27 | Washington | 13 | 12.67 | 48 | 4.2% | 31.3% | .231 | 98% | 28% | 10% | 2.13 | 3.76 |
| Bronson Arroyo | 35 | Cincinnati | 32 | 202.00 | 835 | 4.2% | 15.4% | .292 | 77% | 43% | 7% | 3.74 | 4.12 |
| Jeff Francis | 32 | Colorado | 24 | 113.00 | 502 | 4.4% | 15.1% | .358 | 68% | 51% | 8% | 5.58 | 4.30 |
| Kyle Lohse | 34 | St. Louis | 33 | 211.00 | 864 | 4.4% | 16.6% | .270 | 77% | 41% | 5% | 2.86 | 3.54 |
| Jeremy Hefner | NY Mets | 26 | 93.67 | 408 | 4.4% | 15.2% | .325 | 64% | 45% | 5% | 5.09 | 3.69 | |
| Thomas Layne | 28 | San Diego | 26 | 16.67 | 68 | 4.4% | 36.8% | .250 | 60% | 48% | 0% | 3.24 | 1.21 |
| Raul Valdes | Philadelphia | 27 | 31.00 | 113 | 4.4% | 31.0% | .221 | 69% | 25% | 6% | 2.90 | 2.61 | |
| Kristopher Medlen | 27 | Atlanta | 50 | 138.00 | 520 | 4.4% | 23.1% | .262 | 85% | 55% | 4% | 1.57 | 2.45 |
| Eric Hacker | 29 | San Francisco | 4 | 9.67 | 45 | 4.4% | 17.8% | .387 | 77% | 44% | 11% | 5.58 | 5.09 |
| Matt Lindstrom | 32 | Arizona | 12 | 10.67 | 45 | 4.4% | 22.2% | .312 | 77% | 53% | 0% | 2.53 | 2.10 |
| Brett Myers | 32 | Houston | 35 | 30.67 | 134 | 4.5% | 14.9% | .316 | 70% | 55% | 8% | 3.52 | 4.30 |
| Wade Miley | Arizona | 32 | 194.67 | 807 | 4.6% | 17.8% | .298 | 72% | 44% | 4% | 3.33 | 3.18 | |
| Clayton Richard | 29 | San Diego | 33 | 218.67 | 910 | 4.6% | 11.8% | .276 | 71% | 54% | 9% | 3.99 | 4.65 |
| Sergio Romo | 29 | San Francisco | 69 | 55.33 | 215 | 4.7% | 29.3% | .242 | 91% | 48% | 7% | 1.79 | 2.73 |
| Mike Pelfrey | 28 | NY Mets | 3 | 19.67 | 85 | 4.7% | 15.3% | .358 | 82% | 53% | 0% | 2.29 | 2.42 |
