| 2010 NL Leaders | |||||||||||||
| Name | Age | Team | G | IP | TBF | BB% | K% | BABIP | LOB% | GB% | HR/Air | ERA | FIP |
| Roy Halladay | 33 | Philadelphia | 33 | 250.67 | 993 | 3.0% | 22.1% | .296 | 83% | 53% | 7% | 2.44 | 3.04 |
| Chris Carpenter | 35 | St. Louis | 35 | 235.00 | 969 | 6.5% | 18.5% | .286 | 73% | 51% | 6% | 3.22 | 3.72 |
| Brett Myers | 30 | Houston | 33 | 223.67 | 936 | 7.1% | 19.2% | .294 | 76% | 49% | 6% | 3.14 | 3.59 |
| Randy Wolf | 34 | Milwaukee | 34 | 215.67 | 936 | 9.3% | 15.2% | .284 | 75% | 40% | 7% | 4.17 | 4.88 |
| Tim Hudson | 35 | Atlanta | 34 | 228.67 | 920 | 8.0% | 15.1% | .256 | 81% | 64% | 8% | 2.83 | 4.12 |
| Ryan Dempster | 33 | Chi Cubs | 34 | 215.33 | 918 | 9.4% | 22.7% | .301 | 71% | 48% | 8% | 3.93 | 4.03 |
| Adam Wainwright | 29 | St. Louis | 33 | 230.33 | 910 | 6.2% | 23.4% | .285 | 79% | 52% | 5% | 2.42 | 2.89 |
| Tim Lincecum | 26 | San Francisco | 33 | 212.33 | 897 | 8.5% | 25.8% | .322 | 76% | 49% | 6% | 3.43 | 3.18 |
| Matt Cain | 26 | San Francisco | 33 | 223.33 | 896 | 6.8% | 19.8% | .259 | 75% | 38% | 5% | 3.14 | 3.68 |
| Livan Hernandez | 35 | Washington | 33 | 211.67 | 896 | 7.1% | 12.7% | .300 | 73% | 39% | 4% | 3.66 | 3.98 |
| Ubaldo Jimenez | 26 | Colorado | 33 | 221.67 | 894 | 10.3% | 23.9% | .278 | 76% | 50% | 3% | 2.88 | 3.14 |
| Bronson Arroyo | 33 | Cincinnati | 33 | 215.67 | 880 | 6.7% | 13.8% | .245 | 74% | 45% | 8% | 3.92 | 4.64 |
| Rodrigo Lopez | 35 | Arizona | 33 | 200.00 | 874 | 6.4% | 13.3% | .297 | 68% | 38% | 9% | 5.00 | 5.24 |
| Mike Pelfrey | 26 | NY Mets | 34 | 204.00 | 870 | 7.8% | 13.0% | .312 | 74% | 49% | 3% | 3.66 | 3.86 |
| Clayton Richard | 27 | San Diego | 33 | 201.67 | 860 | 9.1% | 17.8% | .318 | 75% | 47% | 5% | 3.75 | 3.85 |
| Cole Hamels | 27 | Philadelphia | 33 | 208.67 | 856 | 7.1% | 24.6% | .296 | 83% | 47% | 9% | 3.06 | 3.70 |
| Clayton Kershaw | 22 | LA Dodgers | 32 | 204.33 | 848 | 9.6% | 25.0% | .285 | 76% | 42% | 4% | 2.91 | 3.16 |
| Barry Zito | 32 | San Francisco | 34 | 199.33 | 848 | 9.9% | 17.7% | .292 | 72% | 37% | 5% | 4.15 | 4.28 |
| Thomas Hanson | 24 | Atlanta | 34 | 202.67 | 845 | 6.6% | 20.5% | .294 | 71% | 42% | 4% | 3.33 | 3.34 |
| Randy Wells | 28 | Chi Cubs | 32 | 194.33 | 843 | 7.5% | 17.1% | .318 | 72% | 47% | 6% | 4.26 | 3.97 |
| Anibal Sanchez | 26 | Florida | 32 | 195.00 | 841 | 8.3% | 18.7% | .316 | 71% | 46% | 3% | 3.55 | 3.35 |
| Paul Maholm | 28 | Pittsburgh | 32 | 185.33 | 840 | 7.4% | 12.1% | .337 | 65% | 51% | 5% | 5.20 | 4.21 |
| Jon Garland | 31 | San Diego | 33 | 200.00 | 837 | 10.4% | 16.2% | .275 | 76% | 53% | 7% | 3.56 | 4.45 |
| Derek Lowe | 37 | Atlanta | 33 | 193.67 | 824 | 7.4% | 16.5% | .319 | 74% | 58% | 7% | 4.00 | 3.92 |
| Wandy Rodriguez | 32 | Houston | 32 | 195.00 | 822 | 8.3% | 21.7% | .315 | 70% | 48% | 5% | 3.78 | 3.54 |
| Chad Billingsley | 26 | LA Dodgers | 31 | 191.67 | 817 | 8.4% | 20.9% | .313 | 71% | 51% | 3% | 3.57 | 3.11 |
| Johan Santana | 31 | NY Mets | 29 | 199.00 | 817 | 6.7% | 17.6% | .280 | 79% | 37% | 4% | 2.98 | 3.57 |
| Jonathan Sanchez | 28 | San Francisco | 34 | 193.33 | 812 | 11.8% | 25.2% | .259 | 80% | 41% | 7% | 3.07 | 4.03 |
| Ian Kennedy | 26 | Arizona | 32 | 194.00 | 810 | 8.6% | 20.7% | .264 | 76% | 38% | 7% | 3.80 | 4.36 |
| Hiroki Kuroda | 35 | LA Dodgers | 31 | 196.33 | 810 | 5.9% | 19.6% | .297 | 69% | 52% | 5% | 3.39 | 3.30 |
