| 2010 NL Leaders | |||||||||||||
| Name | Age | Team | G | IP | TBF | BB% | K% | BABIP | LOB% | GB% | HR/Air | ERA | FIP |
| Mike Hampton | 38 | Arizona | 10 | 4.33 | 16 | 6.3% | 18.8% | .300 | 100% | 42% | 0% | 0.00 | 2.42 |
| Aaron Miles | 34 | St. Louis | 2 | 2.00 | 8 | 0.0% | 0.0% | .250 | 100% | 25% | 0% | 0.00 | 3.11 |
| Jared Burton | 29 | Cincinnati | 4 | 3.33 | 10 | 0.0% | 10.0% | .0 | 0% | 44% | 0% | 0.00 | 2.51 |
| Steven Cishek | 24 | Florida | 3 | 4.33 | 15 | 6.7% | 20.0% | .91 | 100% | 45% | 0% | 0.00 | 2.42 |
| Hunter Jones | 26 | Florida | 3 | 1.67 | 7 | 14.3% | 42.9% | .0 | 100% | 50% | 0% | 0.00 | 3.11 |
| Craig Kimbrel | 22 | Atlanta | 21 | 20.67 | 88 | 18.2% | 45.5% | .290 | 92% | 25% | 0% | 0.44 | 1.56 |
| Ramon Ramirez | 29 | San Francisco | 25 | 27.00 | 106 | 10.4% | 14.2% | .154 | 93% | 41% | 2% | 0.67 | 3.71 |
| Kenley Jansen | 23 | LA Dodgers | 25 | 27.00 | 109 | 13.8% | 37.6% | .240 | 93% | 37% | 0% | 0.67 | 1.85 |
| Chris Young | 31 | San Diego | 4 | 20.00 | 82 | 13.4% | 18.3% | .167 | 97% | 31% | 3% | 0.90 | 3.91 |
| Hong-Chih Kuo | 29 | LA Dodgers | 56 | 60.00 | 229 | 7.9% | 31.9% | .209 | 86% | 37% | 1% | 1.20 | 1.85 |
| Joe Thatcher | 29 | San Diego | 65 | 35.00 | 137 | 5.1% | 32.8% | .289 | 88% | 41% | 2% | 1.29 | 1.60 |
| Vance Worley | 23 | Philadelphia | 5 | 13.00 | 51 | 7.8% | 23.5% | .219 | 94% | 47% | 5% | 1.38 | 3.19 |
| Javier Lopez | 33 | San Francisco | 27 | 19.00 | 69 | 2.9% | 23.2% | .216 | 77% | 68% | 0% | 1.42 | 1.74 |
| Billy Wagner | 39 | Atlanta | 71 | 69.33 | 268 | 8.2% | 38.8% | .260 | 88% | 39% | 6% | 1.43 | 2.13 |
| Edgmer Escalona | 24 | Colorado | 5 | 6.00 | 26 | 15.4% | 7.7% | .235 | 88% | 32% | 0% | 1.50 | 4.45 |
| Daniel Hudson | 23 | Arizona | 11 | 79.67 | 301 | 5.3% | 23.3% | .219 | 92% | 40% | 6% | 1.69 | 3.25 |
| Ernesto Frieri | 25 | San Diego | 33 | 31.67 | 128 | 13.3% | 32.0% | .246 | 87% | 25% | 4% | 1.71 | 2.96 |
| Roy Oswalt | 33 | Philadelphia | 13 | 82.67 | 316 | 6.6% | 23.1% | .228 | 86% | 51% | 6% | 1.74 | 3.16 |
| Mike Adams | 32 | San Diego | 70 | 66.67 | 268 | 8.6% | 27.2% | .274 | 84% | 42% | 2% | 1.75 | 2.35 |
| J.A. Happ | 28 | Philadelphia | 3 | 15.33 | 70 | 17.1% | 12.9% | .261 | 89% | 36% | 3% | 1.76 | 5.14 |
| Mark Rogers | 24 | Milwaukee | 4 | 10.00 | 36 | 8.3% | 30.6% | .105 | 67% | 50% | 0% | 1.80 | 2.11 |
| Brian Wilson | 28 | San Francisco | 70 | 74.67 | 311 | 8.4% | 29.9% | .324 | 86% | 50% | 3% | 1.81 | 2.23 |
| Tim Stauffer | 28 | San Diego | 32 | 82.67 | 326 | 7.4% | 18.7% | .272 | 84% | 56% | 3% | 1.85 | 3.05 |
| Chris Resop | 28 | Pittsburgh | 22 | 19.00 | 77 | 13.0% | 31.2% | .231 | 86% | 37% | 4% | 1.89 | 2.85 |
| Michael Dunn | 25 | Atlanta | 25 | 19.00 | 88 | 19.3% | 30.7% | .341 | 92% | 35% | 4% | 1.89 | 3.64 |
| Heath Bell | 33 | San Diego | 67 | 70.00 | 287 | 9.8% | 30.0% | .337 | 81% | 44% | 1% | 1.93 | 2.08 |
| Jonathan Venters | 25 | Atlanta | 79 | 83.00 | 350 | 11.1% | 26.6% | .293 | 73% | 69% | 2% | 1.95 | 2.73 |
| Santiago Casilla | 30 | San Francisco | 52 | 55.33 | 225 | 11.6% | 24.9% | .292 | 83% | 50% | 3% | 1.95 | 3.19 |
| Sean Burnett | 28 | Washington | 73 | 63.00 | 261 | 7.7% | 23.8% | .293 | 81% | 55% | 4% | 2.00 | 2.76 |
| Matthew Reynolds | 26 | Colorado | 21 | 18.00 | 70 | 7.1% | 24.3% | .190 | 92% | 40% | 7% | 2.00 | 3.84 |
